By Ernest Giralt,Mark Peczuh,Xavier Salvatella
Protein floor Recognition offers a close remedy of this process, with subject matters including:
- an prolonged survey of protein-protein interactions which are key gamers in human disorder and biology and the possibility of therapeutics derived from this new perspective
- the primary actual concerns that encompass protein-protein interactions that needs to be thought of whilst designing ligands for protein surfaces
- examples of protein surface-small molecule interactions, together with remedies of protein-natural product interactions, protein-interface peptides, and rational ways to protein floor attractiveness from version to organic systems
- a survey of options that would be critical to the invention of recent small molecule protein floor binders, from excessive throughput synthesis and screening suggestions to in silico and in vitro equipment for the invention of novel protein ligands.
Protein floor Recognition offers an highbrow “tool-kit” for investigators in medicinal and bioorganic chemistry seeking to make the most this rising paradigm in drug discovery.
Read or Download Protein Surface Recognition: Approaches for Drug Discovery PDF
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Protein Surface Recognition: Approaches for Drug Discovery by Ernest Giralt,Mark Peczuh,Xavier Salvatella
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