with the intention to meet the ever-increasing calls for for enantiopure compounds, heteroge- ous, homogeneous and enzymatic catalysis advanced independently long ago. even supposing all 3 ways have yielded industrially achievable approaches, the latter are the main common and will be considered as complementary in lots of respects. regardless of the development in structural, computational and mechanistic reports, even though, thus far there is not any common recipe for the optimization of catalytic procedures. hence, a trial-and-error method continues to be main in catalyst discovery and optimization. With the purpose of complementing the well-established fields of homogeneous and enzymatic catalysis, organocatalysis and synthetic metalloenzymes have loved a contemporary revival. synthetic metalloenzymes, that are the point of interest of this ebook, end result from comb- ing an energetic yet unselective organometallic moiety with a macromolecular host. Kaiser and Whitesides advised the potential of developing synthetic metallo- zymes as some time past because the overdue Nineteen Seventies. despite the fact that, there has been a common trust that proteins and organometallic catalysts have been incompatible with one another. This significantly hampered learn during this quarter on the interface among homogeneous and enzymatic catalysis. seeing that 2000, despite the fact that, there was a growing to be curiosity within the box of synthetic metalloenzymes for enantioselective catalysis. the present state-of-the-art and the opportunity of destiny improvement are p- sented in 5 well-balanced chapters. G. Roelfes, B. Feringa et al. summarize study counting on DNA as a macromolecular host for enantioselective catalysis.