Explains how you can practice and examine the result of the most recent physicochemical methods

With this ebook as their advisor, readers have entry to all of the present details had to completely examine and adequately confirm a compound's pharmaceutical homes and their results on drug absorption. The publication emphasizes oral absorption, explaining all of the physicochemical tools used this present day to research drug applicants. furthermore, the writer offers professional counsel to assist readers examine the result of their reviews which will opt for the main promising drug candidates.

This Second Edition has been completely up to date and revised, incorporating all of the most up-to-date study findings, equipment, and assets, including:

• Descriptions and functions of recent PAMPA versions, drawing on greater than thirty papers released via the author's learn group

• Two new chapters analyzing permeability and Caco-2/MDCK and permeability and the blood-brain barrier

• Expanded details and techniques to help pKa determination

• New examples explaining the therapy of essentially insoluble attempt compounds

• Additional case stories demonstrating using the most recent physicochemical techniques

• New, revised, and improved database tables through the book

Well over two hundred drawings aid readers greater comprehend tricky options and supply a visible consultant to complicated systems. moreover, over 800 references function a gateway to the first literature within the box, facilitating extra examine into the entire themes lined within the book.

This Second Edition is suggested as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different comparable parts of analysis. it's also prompt as a supplemental textual content for graduate classes in pharmaceutics.