By Sun Hongmao
This booklet will not be an exhaustive survey masking all facets of rational drug layout. as a substitute, it's going to offer severe information via real-world examples. proper case stories can be provided and analyzed to demonstrate the next: tips on how to optimize a lead compound no matter if one has excessive or low degrees of structural info; how one can derive hits from opponents’ energetic compounds or from common ligands of the ambitions; the right way to springboard from opponents’ SAR wisdom in lead optimization; easy methods to layout a ligand to intervene with protein-protein interactions by way of adequately interpreting the PPI interface; find out how to stay away from IP blockage utilizing info mining; tips to build and completely make the most of a knowledge-based molecular descriptor approach; how one can construct a competent QSAR version through targeting information caliber and correct choice of molecular descriptors and statistical ways. A functional consultant to Rational Drug Design makes a speciality of computational drug layout, with in basic terms simple insurance of biology and chemistry concerns, reminiscent of assay layout, goal validation and artificial routes.
- Discusses various tactics acceptable to day-by-day drug layout
- Readers can obtain the fabrics utilized in the e-book, together with constructions, scripts, uncooked facts, protocols, and codes, making this booklet compatible source for brief classes or workshops
- Offers a distinct perspective on drug discovery learn as a result of author’s cross-discipline schooling background
- Explores the author’s wealthy reviews in either pharmaceutical and educational settings
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A Practical Guide to Rational Drug Design by Sun Hongmao
by William
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